Doctors are warning about the potential dangers of a cosmetic procedure making a comeback: mesotherapy. This procedure involves injecting a mixture of vitamins, minerals, and other substances under the skin to smooth wrinkles, tighten skin, and reduce under-eye bags.
While mesotherapy has been around for decades, it’s recently gained popularity in the U.S. and can be used on areas like the hands, stomach, and under the eyes.

Though marketed as a painless procedure with little downtime, mesotherapy carries risks. Immediately after the procedure, patients may notice small, raised bumps under the skin, creating a temporary “honeycomb” effect. In some cases, people describe the appearance as “reptilian.” However, these bumps usually dissipate over time.

Despite these temporary side effects, doctors caution that the procedure can lead to more serious risks, especially if performed by an inexperienced technician or at home. Potential complications include long-lasting bruising, severe allergic reactions, skin necrosis (tissue death) from improper injection near blood vessels, or permanent damage to the eye.

Additionally, mesotherapy is not a standardized procedure. Each practitioner may use a unique mix of fluids, meaning patients don’t always know what they’re being injected with. Unlike Botox, these substances are not regulated or tested for safety.

While mesotherapy can be effective if performed correctly, there’s a significant risk of complications. For example, the delicate skin under the eyes is vulnerable to damage, and an inexperienced practitioner may cause scarring. Doctors emphasize the importance of seeking out experienced, trained professionals to minimize risks and ensure the best results.